What is Tanshinone 2A?

Tanshinone 2A, also known as total tanshinone, is a fat-soluble phenanthrene quinone compound with effect extracted from the traditional Chinese medicine Salvia miltiorrhiza (Salvia miltiorrhiza root), from which tanshinone I, tanshinone ii a, tanshinone Ⅱ B, cryptotanshinone, isocrypt More than 10 tanshinone monomers including tanshinone, among which 5 monomers of cryptotanshinone, dihydrotanshinone II, hydroxytanshinone, methyl tanshinate, and tanshinone IIB have , and cooling effects. Sodium tanshinone IIA sulfonate, the sulfonated product of tanshinone ii a, can be dissolved in water.

It has been proved by clinical trials that it has a remarkable effect on treating angina pectoris and has few side effects. It is a new drug for treating coronary heart disease. Tanshinone 2A has various functions such as , , promoting blood circulation and removing blood stasis, and promoting wound healing. Long-term use has no obvious side effects.

Basic Information:

Tanshinone 2A Benefits:

1. Bacteriostasis in vitro: tanshinone 2a has a stronger effect on Staphylococcus aureus than berberine, and it also has an inhibitory effect on two kinds of Trichophyton spp.

2. effect Tanshinone ii a has obvious effect after intragastric administration to rats. In the first stage of inflammation model, it has obvious inhibitory effect on the increase of capillary permeability caused by histamine; it has inhibitory effect on acute joint swelling caused by egg white, carrageenan and dextran; it has inhibitory effect on exudative formaldehyde peritonitis effect. In the second phase of inflammation model, it has obvious inhibitory effect on the leukocyte migration of mice induced by gelatin; it has obvious inhibitory effect on subacute formaldehyde joint swelling. For the third-stage inflammation model, the cotton ball granuloma test has no inhibitory effect (that is, no effect in the chronic phase). Tanshinone can reduce the levels of PGF2α and PGE in rat blood, which may be related to the mechanism of tanshinone.

3. Anticoagulant effect Tanshinone 2a has anticoagulant effect. The effect is stronger than that of protocatechuic aldehyde.

4. Other effects Tanshinone ii a can improve the survival rate or prolong the survival time of mice under hypobaric hypoxia. Tanshinone has anti-androgen effect, reduces sebum production, has anti-Propionibacterium acnes effect, and reduces inflammation exacerbated by bacterial metabolism. Can be used to treat acne. Tanshinone has effect on rabbits caused by typhoid vaccine. Experiments in mice have shown that tanshinone has a milder, ovarian-acting estrogenic activity.

5. Observing the in vivo process of tanshinone entering the liver and being excreted by the bile after the administration of tanshinone through the duodenum. The results show that a small amount of tanshinone in the bile can be detected in about 1 hour after the administration of the rat duodenum. , and its excretion peak is about 3 hours after administration. Tanshinone with different structures has different excretion speed in the liver. In addition, the experiment also found that after the tanshinone in the bile was extracted with chloroform, denatured protein was precipitated in the aqueous solution of the bile, and its content had a certain relationship with different administration groups.

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