What is luteolin powder?

Luteolin powder is a natural flavonoid compound that exists in many plants. It has a variety of pharmacological activities, such as , , lowering uric acid, , , , etc. It is mainly used clinically to relieve cough, expectorant, , lower uric acid, treat cardiovascular diseases, and treat "muscular atrophic spinal cord." "Cable sclerosis", SARS, hepatitis, etc.

Luteolin powder is widely distributed in nature. It is named because it was originally isolated from the leaves, stems, and branches of the Resedaceae luteolin genus herb, Resedaodorata L., and can be derived from a variety of natural medicinal materials, Isolated from vegetables and fruits. The current discovery is mainly found in natural medicinal materials such as honeysuckle, chrysanthemum, nepeta, Prunella vulgaris, artichoke, perilla, scutellaria, nudiflora and other natural medicinal materials, as well as Brussels sprouts, cabbage, cauliflower, beets, broccoli, carrots , Celery, sweet peppers, peppers, groundnuts and other vegetables and fruits, other plant products such as olive oil and red wine, as well as wild impatiens, thyme, lamiaceae whole-leaf green bluegrass, ajuveniles, etc. also contain luteolin.

Tamarindus indica pulp does not contain luteolin, but the husk contains luteolin. There have been reports of luteolin in the leaves of capers.

Basic Information:

Luteolin Powder Benefits:

1.

It is currently believed that the activity of luteolin can inhibit the production of nitric oxide (NO) and other inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and inhibit protein Tyrosine phosphorylation is related to gene expression mediated by nuclear transcription factor KB (NF-KB).

2.

The mechanisms of action are many and complex. Studies have shown that luteolin bulk powder can selectively inhibit the fatty acid synthase activity of prostate cancer and breast cancer cells, which is related to its cell growth and apoptosis; luteolin can be significant Reduce the incidence of colon cancer and tumor size caused by dimethylhydrazine, which is related to its ability to regulate lipid peroxidation, , and anti-proliferation; luteolin can inhibit the invasion and movement ability of ovarian cancer cell HO8910PM in a dose-dependent manner in vitro It is related to its inhibition of the secretion of matrix metalloproteinase-9 (MMP-9) and down-regulation of the expression of extracellular signal-regulated kinase 2 (ERK2).

3.

Luteolin bulk powder can inhibit immunoglobulin E (IgE)-mediated allergy transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and the release of monocyte-macrophage colony stimulating factor. The effect may be related to the inhibition of Ca2+ influx and protein kinase C (PKC) translocation activation.

4. demyelinating diseases

Luteolin can protect oligodendrocytes against oxidative damage induced by hydrogen peroxide in a dose-dependent manner in vitro, strongly inhibit the phagocytosis of myelin by macrophages, significantly reduce the production of cellular reactive oxygen species, and reduce the expression of iNOS protein. At low doses, the level of NO produced by macrophages was significantly reduced.

5. Anti-fibrosis

Luteolin powder can reduce the degree of liver fibrosis, reduce the content of hydroxyproline (HYP), malondialdehyde (MDA) and the expression of type I procollagen mRNA in liver tissues, and can inhibit hepatic stellate cells (HSC) in vitro Proliferation and collagen synthesis. It can also improve the histopathological changes of pulmonary fibrosis caused by bleomycin, reduce lung mass index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue , In vitro can inhibit the proliferation of human embryonic lung fibroblasts and promote their apoptosis.

6. Anti-fertility and hormone effects

Luteolin has significant dose-dependent anti-implantation activity. After oral administration, it can significantly increase the weight and diameter of the uterus, the thickness of the endometrium and the height of its epithelial cells. When alcohol is used in combination, it has an anti-estrogen effect.

7. The effect on blood vessels

Luteolin can inhibit vascular endothelial growth factor (VEGF)-induced rabbit corneal angiogenesis in vivo; it can inhibit tumor growth and angiogenesis in murine xenograft tumor models; it can inhibit VEGF-induced human umbilical vein endothelial cells (HUVECs) in vitro Survival and proliferation. It can significantly inhibit the proliferation and DNA synthesis of vascular smooth muscle cells induced by platelet-derived growth factor-BB (PDGF-BB), and can block the cell cycle in the G1 phase. It can concentration-dependently reduce the tension of phenylephrine pre-constricted blood vessels, antagonize the vasoconstriction caused by high potassium, have arterial relaxation, and its vasodilation effect is not endothelial-dependent, and its mechanism of action is directly related to the direct inhibition of voltage-dependent calcium channels, Receptor-operated calcium channels, intracellular calcium release, and activation of potassium channels are related, but have nothing to do with α and β receptors.

8. Other

Luteolin powder can inhibit a variety of bacteria and viruses, such as Staphylococcus aureus, Escherichia coli, herpes simplex virus, polio virus, Coxsackie B3 virus and so on. It can inhibit the activity of HIV-1 integrase of HIV, and has a potential anti-HIV effect. Luteolin can bind to the s2 protein of the severe acute respiratory syndrome (SARS) coronavirus, thereby inhibiting the virus from entering the host cell. Luteolin also has the effect of resisting Leishmania donovani, and inhibits its growth by inhibiting the effects of Leishmania donovani topoisomerase I and topoisomerase II. In addition, luteolin also has immunomodulatory effects.

Application:

1.luteolin powder has the function of , and ; luteolin asthma

2.luteolin powder has effect. Especially having a good inhibition on prostate cancer and breast cancer;

3.luteolin powder has the function of relating and protecting vascular;

4.luteolin powder can reduce the level of hepatic fibrosis and protect liver cells from damage

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