What is Polygonum Multiflorum Extract?

Polygonum multiflorum extract is an effective ingredient extracted from the dried root tuber of Polygonaceae plant Polygonum multiflorum. The main functional components are lecithin, emodin, rhein and other ingredients. Main functions: effect, influence on the immune system, hypolipidemic and anti-atherosclerotic effect, myocardial protection, liver protection, neuroprotection, effect.

Source plant: Polygonum multiflorum, also known as Shouwu, Red Shouwu, Red Neixiao, Goblin, Horse Liver Stone, etc. Polygonum multiflorum is the dry root tuber of Polygonum multiflorum Thunb.

It is warm in nature, bitter, sweet and astringent in taste. Detoxify, relieve pain, moisten the intestines and laxative. For scrofula carbuncle, rubella itching, dry bowel constipation, hyperlipidemia.

Polygonum multiflorum root extract nourishes liver and kidney, nourishes essence and blood, black hair, and strengthens bones. Used for blood deficiency and chlorosis, dizziness, tinnitus, early white hair, waist and knee weakness, numbness, uterine bleeding, chronic malaria, physical weakness, hyperlipidemia.

Polygonum multiflorum extract is used for Anti-aging effect on the immune system,. Hypolipidemic and anti-atherosclerotic effect. Protection of myocardial function, protect the liver, protecting nerve function, effect, other effects: Polygonum with adrenal cortical hormone-like effect.

Certificate of Analysis:

Polygonum Multiflorum Benefits :

Polygonum Multiflorum Extract (PM) has been used traditionally to treat different systemic diseases and acclaimed for various biological activities including ,radical scavenging activity, lipid regulation, and hair-follicle growing.

1) Cognitive Impairment

A Chinese clinical trial of 209 Alzheimer's disease patients found significant benefits of Fo-ti extract for cognitive decline, but it lacked a placebo control. In another Chinese study (166 participants), a combination of Korean ginseng and Fo-ti improved mild cognitive impairment.Tetrahydroxystilbene glucoside from Fo-ti helped with memory deficit in mouse models of Alzheimer's .

In test tubes, Fo-ti root extract reduced amyloid plaque that can cause Alzheimer's disease. Emodin, a chemical found in Fo-ti, inhibits the enzyme that breaks down acetylcholine, which might contribute to its pro-cognitive effects.

2) Heart Disease

An herbal mixture containing Fo-ti significantly reduced LDL cholesterol and triglycerides in a study of 42 participants. Other ingredients have likely contributed to the results.

In rats, TSG protected the heart from squeezing pressure around the abdomen.TSG prevented atherosclerosis by reducing lipid levels in the blood and suppressing inflammation (via the MMP-2 and MMP-9 genes) in another study on rats.

In a cellular model of a heart attack, polygonum multiflorum root extract stilbene glycoside prevented heart cell injury and boosted s such as superoxide dismutase, glutathione peroxidase, and the nitric oxide pathways.Further research is required to understand the potential heart-friendly effects of Fo-ti.

3) Effects

TSG and emodin in Polygonum Multiflorum Extract decreased inflammation and helped with colitis in mouse models by increasing PPAR-gamma and decreasing NF-kB.In test tubes, a methanol extract of Fo-ti had an effect on the immune cells stimulated by bacterial toxins. It inhibited NF-kB activation and thus reduced nitric oxide, COX-2 enzyme, and inflammatory cytokines like TNF-alpha and IL-6.

4) Immune-Stimulating Effects

Strengthening of the immune system is one of the traditional Fo-ti uses.The sugars (rhamnose, arabinose, xylose, and glucose) and anthraquinone glycosides from Fo-ti have immune-stimulating properties.In test tubes, scientists observed the potential of Fo-ti to stimulate the production and activity of T cells, B cells, and natural killer (NK) cells.

5) Effects

Fo-ti had activity against methicillin-resistant Staphylococcus aureus (MRSA) in one cell-based study.

6) Asthma

In a mouse model of asthma, researchers observed the ability of Fo-ti to reduce airway inflammation and constriction.

7) Bone Health

Hot water extract of polygonum multiflorum root extract prevented bone loss (osteopenia) in a study on menopausal mice.TSG from Fo-ti extract protected the bone-making cells (osteoblasts) from oxidative stress in a cell-based study.

8) Diabetes Complications

TSG protected diabetic mice against kidney damage from high blood sugar through SIRT1 and TGF-beta pathways. In test tubes, stilbene glucoside from Polygonum Multiflorum Extract inhibited tissue aging due to high blood sugar.

9) Parkinson's Disease

In mouse models of Parkinson's Disease, TSG and an ethanol extract of Fo-ti protected dopaminergic neurons from chemical-induced damage.

10) Brain Protection

Extracts of Fo-ti prevented brain tissue damage following a stroke in one study on mice. In a cell-based study, Fo-ti protected neuronal cells from the hippocampus against high glutamate toxicity.

11) Metabolic Syndrome

Fo-ti, together with red ginseng, helped with metabolic syndrome in a study on rats by improving:

High blood pressure

Obesity

High blood lipids

Inflammation of the blood vessels

Insulin sensitivity

12) Effects

Scientists observed the potential of emodin from Fo-ti to suppress the growth of colon and gallbladder cancer in mice. Polygonum multiflorum root extract components showed inhibitory effects against various types of cancer cells in test tubes, but this doesn’t reveal much about their potential effects in living beings.

Much more research is needed to evaluate the potential effects of Fo-ti. According to the available evidence, it can not be suggested as a complementary approach for cancer treatment or prevention.

13) Hair Growth

Fo-ti has traditionally been used to treat patients suffering from baldness and hair loss throughout East Asia. In a study on mice, Polygonum Multiflorum Extract promoted hair growth by stimulating hair follicles.

Torachrysone-8-O-β-D-glucoside, a compound found in P. multiflorum, can significantly increase the number of dermal papilla cells which play a role in hair growth and hair fiber length.

Polygonum Multiflorum Extract Application:

1.Polygonum multiflorum root extract can be applied in food field, it is used in coffee and other drinks;

2. It can be applied in health product & pharmaceutical field, as raw material of aphrodisiac gellants, it is often added in health food and drugs;

3.Besides, it can be applied in food field, it is an ingredient which can be added in cosmetics.

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