What is Glabridin?

Glabridin is a substance compound that is found in the root concentrate of licorice (Glycyrrhiza glabra). Glabridin is an isoflavane, a kind of isoflavonoid. This item is important for a bigger group of plant-inferred particles, the normal phenols. Glabridin 40 may be used as a treatment for thromboembolic disorders because it effectively blocks platelet activation.

It is listed in the International Nomenclature of Cosmetic Ingredients (INCI) as a cosmetic ingredient.

A brownish-yellow powder is glabridin. It is soluble in organic solvents like propylene glycol but insoluble in water.

Basic Information:

Glabridin Benefits:

Glycyrrhiza glabra has whitening, and other effects. Glycyrrhiza glabra extract can penetrate deep into the skin and maintain high activity, effectively inhibit melanin production, and is an efficient, safe, and green cosmetic ingredient for whitening and removing freckles. Glycyrrhiza glabra extract has the functions of preventing rough skin, anti-inflammation and , and , anti-ultraviolet, whitening and brightening, and freckle removal. Glycyrrhiza glabra is known as whitening gold, and licorice glabra can accelerate the metabolism of peroxide lipids in the human body.

The main effects of licorice glabra extract are: inhibiting the activity of tyrosinase (whitening), and the ability to scavenge oxygen free radicals () similar to SOD (superoxide dismutase) and vitamin E. It is an available High-quality active substances for and , , , anti-ultraviolet, whitening and brightening skin and freckle removal.

1.

Zhao Quanmin and others have studied the ability of glabridin, and the results of drug sensitivity experiments show that (Table 1), glabridin is effective against Staphylococcus aureus ATCC25923, Staphylococcus aureus ATCC29213, Enterococcus faecalis ATCC29212, and Escherichia coli ATCC25922. The MIC (Minimum Inhibitory Concentration) of glabridin was 4 μg/mL, 4 μg/mL, 32 μg/mL and 256 μg/mL, respectively, that is, glabridin had activity against these tested standard strains.

2.

The mechanism of glabridin extract is mainly to reduce the expression of chemokines and pro-inflammatory factors, inhibit inflammatory factors, and inhibit steroid metabolic enzymes to produce effects synergistically. The activity of glabridin was first confirmed in 1998. At a concentration of 6.25 μg/mL, glabridin can effectively inhibit the activity of COX (cyclooxygenase) stimulated by arachidonic acid, and the inhibition rate is 31.9%.

Studies have shown that this cell line originally releases a large amount of phospholipids because COX-2, nuclear factor NF-κB, and transcription factor activator protein-1 of microglia and murine macrophages were significantly down-regulated after the cells were intervened with glabridin. Inflammatory factors (such as: interleukin IL-1, tumor necrosis factor TNF-α, NO, prostaglandin PGE2) were significantly reduced after glabridin was used to intervene in cell culture.

3.

Zheng Yating studied the inhibitory ability of glabridin on DPPH and compared it with vitamin C.

4. Whitening

Zheng Yating used mushroom tyrosinase activity test, α-MSH (α-melanocyte hormone) induced intracellular tyrosinase activity test and intracellular melanin content test in B16 melanoma cells to study the reduction of melanin production by glabridin in vitro role.

Glabridin 40 belongs to traditional Chinese medicine plants, and its roots and rhizomes are mostly used. The chemical components include triterpenoid saponins with glycyrrhizic acid and glycyrrhetinic acid as the main components; Organic acids, etc., mainly have whitening, , , effects; they can also prevent skin aging, scavenge free radicals and superoxide ions, and inhibit the activity of tyrosinase; they can be used in cosmetics for sun protection, Whitening, and treatment of skin diseases.

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