What is Lentinan?

Lentinan is a polysaccharide isolated from the fruit body of shiitake mushroom (Lentinula edodes mycelium).Lentinan is a β-1,3 beta-glucan with β-1,6 branching. It has a molecular weight of 500,000 Da and specific rotation of +14-22° (NaOH).

An in vitro experiment showed lentinan stimulated production of white blood cells in the human cell line U937.Lentinan is thought to be inactive in humans when given orally and is therefore administered intravenously. The authors of an in vivo study of lentinan suggested that the compound may be active when administered orally in mice.

Basic Information:

Lentinan Benefits:

Lentinan is a substance that comes from the shiitake mushroom. Medical professionals use lentinan to boost the effects of regular medicines used for treating cancer and HIV infection. They give lentinan intravenously (by IV) or as a shot (by injection).

1. activity of lentinan

Lentinus edodes polysaccharide has an effect, and it has no toxic side effects of chemotherapy drugs. After the lentinan enters the antibody, it induces an immunologically active cytokine. Under the combined action of these cytokines, the body’s immune system is enhanced and it plays a defense and killing effect on the tumor cells.

Lentinus edodes polysaccharide enhances antibody-dependent cell-induced cytotoxicity (ADDC) by activating macrophages, and exerts activity; in addition, lentinan can cause blood vessel dilatation and hemorrhage at the tumor site, resulting in tumor hemorrhage, necrosis and complete degeneration.

2. Immunomodulation of lentinan

The immunomodulatory effects of lentinan extract are an important basis for its biological activity. Lentinus edodes is a typical T cell activator that promotes the production of interleukins and promotes the function of mononuclear macrophages. It is considered to be a special immune enhancer. Its immune function is characterized by its ability to promote the production of lymphocyte activating factor (LAE), release various helper T cell factors, enhance the phagocytic rate of host peritoneal macrophages, and restore or stimulate the function of helper T cells. In addition, lentinan also promotes antibody production and inhibits macrophage release.

3. activity of lentinan

Dr. Ishida of Japan believes that shiitake mushrooms contain a double-stranded ribonucleic acid that stimulates the release of interferon from human reticular cells and white blood cells, while interferon has an effect. The mycelium extract of shiitake mushroom can inhibit the adsorption of herpes virus by cells, thereby preventing various diseases caused by herpes simplex virus and cytomegalovirus. The United Kingdom extracts a substance from the cultured shiitake mycelium, which can restore the HIV-infected T lymphocytes, stimulate macrophages, help produce antibodies to treat AIDS, and is safe and has no side effects.

Some scholars have found that sulfated lentinan has anti-HIV (HIV) activity, which can interfere with the adsorption and invasion of retroviruses and other viruses. Japanese scholars have reported that a sulfated derivative of glucan with good activity obtained from the fruiting body of Lentinus edodes can inhibit the activity of HIV.

4. Anti-infective effect of lentinan

It has been reported that lentinan extract can increase macrophage function. Lentinus edodes polysaccharide has inhibitory effects on Abelson virus, adenovirus type 12 and influenza virus infection, and is a good drug for treating various hepatitis, especially chronic migratory hepatitis.

Undersun's Lentinan

Competitive advantage:

Selected raw materials, Sufficient stock, quick shipment from USA warehouse, own manufacturer produce and export directly, price advantage and good service, Timely communication, strong technical service team, mixing and blending as customer’s formula

Quality Standard:

Conform to QB standards.

Production process flow chart:

Shitake Mushroom raw material →Screening→Extracted with water→Filtration→

Concentration→Crystallization→Drying→Screening→Sieving→Detection→Packaging.

Packing & Storage :

Packing: 25Kg/Fiber Drum, double plastic bag inside.

1Kg/Bag, aluminum foil bag vacuum packing

Or customized.
Storage: Kept away from strong light and heat.
Shelf Life: 24 months for powder

Logistics transportation:

Payment term:

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Riley Gao， [email protected]

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