What's in Myricetin?

Myricetin is a member of the flavonoid class of polyphenolic compounds, with properties. Common dietary sources include vegetables (including tomatoes), fruits (including oranges), nuts, berries, tea, and red wine. Myricetin is structurally similar to fisetin, luteolin, and quercetin and is reported to have many of the same functions as these other members of the flavonol class of flavonoids. Reported average intake of myricetin per day varies depending on diet, but has been shown in the Netherlands to average 23 mg/day.

Myricetin is produced from the parent compound taxifolin through the (+)-dihydromyricetin intermediate and can be further processed to form laricitrin and then syringetin, both members of the flavonol class of flavonoids. Dihydromyricetin is frequently sold as a supplement and has controversial function as a partial GABAA receptor potentiator and treatment in Alcohol Use Disorder (AUD). Myricetin can alternatively be produced directly from kaempferol, which is another flavonol.

Basic Information:

Myricetin Benefits:

Myricetin is mainly present in the glycoside form (O-glycosides), in vegetables, fruits, nuts, berries, herbs, plants together with beverages, such as tea, wine, fruit and medicinal plants. There are numerous factors that can influence myricetin levels in plant foods such as genetic and environmental factors, germination, and ripeness degree, variety, seasonal variation, and storage, processing and cooking. The estimate of total flavonoid intake is difficult to calculate, as appropriate tables of food composition are not yet available. However, reliable data on daily flavonoid intake in a population are needed to develop proper dietary recommendations and even for correct data interpretation from intervention studies. The Flemish Dietetic Association database determined an average daily intake of myricetin of 2.2 ± 2.5 mg Mullie et al.

In a Korean adult population, Jun et al. estimated an average intake of 0.8 mg/day representing about 1–2% of flavonol subclass, while a mean intake of myricetin 2 mg/day ranged from 1 to 4 mg/day in adults (18 to 64 years) in the European Union was reported by Vogiatzoglou et al. The knowledge on habitual flavonoids consumption is also crucial to determine their possible impact on human health. Myricetin exhibited properties and free radical-scavenging effects. These activities seem to support a wide range of beneficial outcomes including, anti-platelet aggregation, antihypertensive, immunomodulatory, , , analgesic, actions and so on. The main goal of the present review is to provide new insights on myricetin preclinical pharmacological activities, and its role in selected clinical trials.

Myricetin Application:

1. Applied in foods field.

2. Applied in cosmetics field.

3. Applied in health products field.

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