What is Rhodiola Root Powder?

Rhodiola Root Powder has been a prominent herb in Europe and Asia for its adaptogenic properties and has only recently become popular in North America. Occasionally referred to as stonecrop, wild Rhodiola rosea stands have been experiencing the results of overharvest from high consumer demand. We work with sustainably-minded farmer partners for an organically cultivated supply of this beloved root. Rhodiola powder is often tinctured and used for encapsulating.

Now certified organic! The floral scented rhodiola root, used for thousands of years in Europe and Asia, has just recently been introduced to the U.S. Traditionally; one of its main uses in the Himalayas was for occasional altitude related discomforts.

Basic Information:

Rhodiola Root Extract Benefits:

Potential Benefits

Rhodiola has produced positive results in at least one study on each of the potential benefits in this section, but larger and more robust studies are required to confirm its effectiveness. The FDA has not approved rhodiola or its extracts for any medical purpose or health claim. Talk to your doctor before starting a new supplement.

Possibly Effective For

1) Stress Relief

Rhodiola rosea is an adaptogen: a compound purported to combat stress by helping the body (and especially the brain and the immune system) return to and maintain a normal, balanced state.

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Fatigue

In a handful of human studies, rhodiola extracts reduced feelings of fatigue in university students and young physicians.Reductions in fatigue were significant compared to the placebo groups, but the studies were small and brief.

HPA Axis

Salidroside, like many adaptogens, acts on the HPA axis: the hypothalamus, the pituitary gland, and the adrenal gland. This system of glands controls many of the body’s stress responses, such as the release of cortisol.

Mood Mechanisms

Rhodiola extracts, especially salidroside, may decrease the symptoms of depression and generally improve mood [20, 21].

In cell studies, rhodiola extract directly activated four important neurotransmitters: norepinephrine, serotonin, dopamine, and acetylcholine. Low dopamine, in particular, is strongly associated with depression and often overlooked; this plant’s effect on dopamine may explain its mood-lifting effects [22, 23].

In one study, salidroside from Rhodiola significantly decreased inflammatory cytokines and returned neurotransmitter levels to normal in rat brains. These two effects are probably linked; inflammation often contributes to depression [20, 24].

Its potential may also come from an ability to inhibit monoamine oxidase (MAO) in cells. MAO breaks down neurotransmitters while blocking them can raise neurotransmitter levels [25].

Monoamine oxidase is also the target of some drugs like selegiline, phenelzine, and isocarboxazid. This class of drugs may interact dangerously with rhodiola; see the section on drug interactions below [26, 27].

Rhodiola extract directly activates norepinephrine, serotonin, dopamine, and acetylcholine on direct contact with cells.

Insufficient Evidence For

The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of Rhodiola Root Powder for any of the below-listed uses. Remember to speak with a doctor before taking rhodiola supplements, and never use them in place of something your doctor recommends or prescribes.

2) Sexual Function

Rhodiola is sometimes marketed as a libido booster or a remedy for erectile dysfunction. In combination with zinc, folic acid, and biotin, it may be useful for premature ejaculation [28].

However, many claims about improved sexual function originate from a single study. This study, which was conducted on 120 adults over 50, did not include a placebo or control group and was not focused solely on sexual function, but on a variety of physical and cognitive symptoms [29, 30].

In fact, Rhodiola’s potential effect on sexual function is probably linked to its properties. One study found that it reduced all symptoms in people with burnout, including sexual dysfunction [14].

Sexual function and stress are, of course, closely related. By increasing stress resilience and s, this adaptogen may contribute to a healthy libido. In other cases, though, sexual and erectile dysfunction are not linked to stress. In those cases, Rhodiola probably won’t have an effect [14].

All in all, Rhodiola may improve sexual function, especially in people suffering from mental health issues and erectile dysfunction, but much more research is required.

Some people use rhodiola to improve sexual function, but the evidence for this benefit comes from only a single clinical trial of older adults.

Animal & Cell Research (Lacking Evidence)

No clinical evidence supports the use of rhodiola for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.

3) Cognition

Nootropics are an eclectic group of substances believed to enhance brain function. The widely-used nootropic is caffeine; a variety of plants may also have nootropic effects, such as ginseng, ginkgo, turmeric, and sage (Salvia) [31, 32, 33, 34].

Some users believe that rhodiola is a nootropic. In animal models, it stimulated activity in the brain and activated the neurotransmitters norepinephrine, serotonin, dopamine, and acetylcholine. However, this has not been observed in human trials [35, 22].

Rhodiola could potentially increase wakefulness and reduce both physical and mental fatigue, but this has not been studied in humans [36, 37, 38].

Some people use rhodiola as a nootropic, but there is no human evidence on which to base any claim of cognitive benefit.

4) Immune System

Rhodiola extract could potentially improve the body’s natural immune response to threats from bacteria and viruses.

5) Activity

Free radicals are potentially harmful molecules that are produced during energy metabolism in a healthy cell. Free radicals are completely natural, but they need to exist in balance with s to prevent excessive oxidative stress, which can damage fats, proteins, and DNA. Unfortunately, a lot of free radicals can be created through exposure to radiation or to harmful substances like cigarette smoke, air pollutants, and industrial chemicals [45].

Aging

Rhodiola Root Powder’s activity may help fight aging, although the mechanisms are not well-studied in humans [51, 22].

6) Bacteria & Acne

Extracts and dried Rhodiola root can kill the bacteria directly exposed to them. In one study, it could fight every species of bacteria studied, including the common disease-causing Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli.

Rhodiola and its extracts have yet to be studied in human acne trials.Rhodiola extracts have demonstrated activity and the ability to disrupt biofilms on direct contact. Clinical studies on acne should be forthcoming.

7) Inflammation

JAK2 and STAT3 are two genes that, when combined, form a pathway that increases inflammation. Salidroside prevents the JAK2-STAT3 pathway from being activated; in this way, it decreases inflammation.

Rhodiola Root Powder may selectively decrease the inflammatory cytokines IL-1, IL-6, and TNF-alpha. Its extracts may reduce the expression of these cytokines throughout the body. In one study of mice injected with an E. coli toxin, a large dose of Rhodiola extract significantly lowered inflammation in the kidney and brain.

8) Brain Health

By activating AMPK, Rhodiola may protect nerves and neurons from damage in Alzheimer’s disease and brain injury [61, 62, 47].

9) Heart Health

In the heart and elsewhere in the body, AMPK maintains an oxidative balance: in response to oxidative stress, AMPK activates genes that produce proteins and reduces blood pressure. Mutations in the AMPK gene can cause problems with heart rhythm and cause Wolf-Parkinson-White syndrome, a rare heart condition [68, 69].

10) Lung Health

We need oxygen to flow constantly through our lungs, but the combination of toxins and oxygen in excess can produce a dangerous cocktail of free radicals and oxidative stress. The lungs are especially vulnerable to oxidative stress.

In the lungs, oxidative stress over a long period of time can lead to asthma, respiratory cancers, and chronic obstructive pulmonary disease, or COPD.Possibly by increasing the expression of proteins and reducing inflammatory cytokines, salidroside from Rhodiola protected against oxidative damage to the lungs of rats.

Some researchers have recommended further study on rhodiola for its potential to protect the lungs from oxidative stress and inflammatory diseases like asthma or COPD.

11) Pain Management

In multiple studies, rhodiola and its extracts reduced pain and swelling in rats with diabetes, arthritis, and injury.Both of its major active components, salidroside and rosavin, appear to reduce pain by decreasing inflammation. In this sense, they are similar to many commonly-used painkillers (like NSAIDs).

rhodiola root powder dosage

There is no safe and effective dose of rhodiola or its extracts because no significantly powered study has been conducted to find one. Furthermore, the FDA has not approved rhodiola for any medical purpose or health claim, and in fact, classifies Rhodiola rosea and some related species as poisonous plants.

That being said, it has had a favorable safety profile and produced some promising results in clinical trials.

Rhodiola rosea supplements are available as caplets, tea, or liquid extracts. High-quality extracts, such as those used in medical research, contain at least 3% rosavins and 1% salidroside. Other species of Rhodiola, such as R. crenulata, may contain a much higher concentration of salidrosides [84, 85, 86].

A recent study on Rhodiola supplements found good results with 400 mg/day of dry Rhodiola extract (or 300 – 1,000 mg of the root) to effectively reduce the symptoms of chronic fatigue [37].

Some psychiatrists may recommend rhodiola as part of a strategy to improve ADHD and focus/learning difficulties. One doctor advises his patients to gradually build up to and not exceed 450 mg/day (three 150 mg capsules) and taking the extract half an hour before a meal [1].

Consult your own doctor before taking rhodiola supplements.

Rhodiola Root Extract Application:

1. Applied in food fields, it is widely used as functional food additive;
2. Applied in health product field, it can be used as raw material in health food, the purpose is to enhance immunity and resist melancholy;
3. Applied in cosmetics fields, it is widely used to delay aging and compact skin;
4. Applied in pharmaceutical field, it is widely used to treat cardio-cerebrovascular disease.

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