Taxifolin (5,7,3',4'-flavan-on-ol), also known as dihydroquercetin, belongs to the subclass flavanonols in the flavonoids, which in turn is a class of polyphenols.
Taxifolin has two stereocenters on the C-ring, as opposed to quercetin which has none.For example, (+)-taxifolin has (2R,3R)-configuration, making it 1 out of 4 stereoisomers that comprise 2 pairs of enantiomers.
Dihydroquercetin taxifolin is found in non-glutinous rice boiled with adzuki bean (adzuki-meshi).
It can be found in conifers like the Siberian larch, Larix sibirica, in Russia, in Pinus roxburghii,[5] in Cedrus deodara[5] and in the Chinese yew, Taxus chinensis var. mairei.
It is also found in the silymarin extract from the milk thistle seeds.
Dihydroquercetin taxifolin is present in vinegars aged in cherry wood.
Taxifolin, and flavonoids in general, can be found in many beverages and products. Specifically, taxifolin is found in plant-based foods like fruit, vegetables, wine, tea, and cocoa.
Product Name: | dihydroquercetin | ||
Latin Name: | Taxifolin | ||
From | leaf | ||
Specification: | 98% | ||
Appearance: | light yellow fine powder | ||
Test Method: | HPLC | ||
Shelf Life: | 2 Years | ||
Storage: | Cool and dry place |
Taxifolin showed promising pharmacological activities in the management of inflammation, tumors, microbial infections, oxidative stress, cardiovascular, and liver disorders. The activity was more prominent than other activities evaluated using different in vitro and in vivo models. Further research on the pharmacokinetics, in-depth molecular mechanisms, and safety profile using well-designed randomized clinical studies are suggested to develop a drug for human use.
A proven , at least three times more effective than quercetin, with which it shares many similarities, taxifolin has been the subject of over 600 studies over the last 50 years, most of which have examined its efficacy, safety and mechanisms of action on the vascular system. These studies, which focus on its potential to inhibit oxidation of LDL cholesterol and to reduce blood viscosity, have significantly expanded our understanding of this flavonoid though they have not yet resulted in a scientific consensus as to its therapeutic use.
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